Corrigendum: Asymmetric Grignard Synthesis of Tertiary Alcohols through Rational Ligand Design.
نویسندگان
چکیده
A simple, general and practical method is reported for highly enantioselective construction of tertiary alcohols through the direct addition of organomagnesium reagents to ketones. Discovered by rational ligand design based on a mechanistic hypothesis, it has an unprecedented broad scope. It utilizes a new type of chiral tridentate diamine/phenol ligand that is easily removed from the reaction mixture. It is exemplified by application to a formal asymmetric synthesis (>95:5 d.r.) of vitamin E.
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 56 52 شماره
صفحات -
تاریخ انتشار 2017